Helping The others Realize The Advantages Of ceesdekker.net
Helping The others Realize The Advantages Of ceesdekker.net
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Utilizing single-molecule optical and AFM imaging and drive-spectroscopy tactics, we seek out to unravel the mechanistic elements of the composition and dynamics of chromosomes. Our exploration interests include:
Our group research bacterial cell division and is particularly aiming to represent a ‘bottom up biology’ in artificial cells which will autonomously divide. Our major curiosity lies in cell division, chromatin composition, and spatial Management.
Multicolor imaging from the bacterial nucleoid and mobile division proteins with blue, orange, and in the vicinity of-infrared fluorescent proteins
Due to the fact 2000, Dekker has shifted the principle aim of his do the job in the direction of biophysics the place he studies the Qualities of solitary biomolecules and cells utilizing the applications of nanotechnology. This change of discipline was pushed by his fascination with the outstanding functioning of biological molecular structures, and also because of the extensive-term point of view a large number of interesting discoveries may be anticipated In this particular subject.[five] Latest strains of investigate in his biophysics team are within the areas of:[6]
That is a desire of mine and we established to work that has a tasty dose of naivety. This is often something that will most likely generate magnificent ends in the for a longer period phrase, but that does not make any difference. You should not only want to work to the questions of tomorrow, but additionally to the thoughts from the day soon after tomorrow.’
Our investigation ranges with the biophysics of DNA to artificial cells and over and above. Remember to have a look beneath on the spectrum of our existing tasks.
All parameters were being exactly the same for each panel On this movie, aside from the First placement of your 6hb rod (shown in blue) around the nanopore. Simulations that terminated early as a result of translocation on the rod from the pore are marked by a gray background.
Dynamic ParB–DNA ceesdekker.net interactions initiate and retain a partition condensate for bacterial chromosome segregation
‘Indeed, I understand folks were being stunned at some time. At the end of the nineties, Once i was in my forties, I had been Professor of Molecular Electronics and I have to admit that it experienced turn into a bit bored, I didn’t understand much anymore. The sphere went much more into the appliance facet, how you can combine nanotubes into Digital circuits.
Resolving the action dimensions in condensin-pushed DNA loop extrusion identifies ATP binding as being the phase-creating approach
‘The concept that You can find such a factor being a commencing, a big bang, is presently a fascinating signpost to look at that there was a creator. But more usually, and on the basis of pure rationality, I also arrive at a Christian interpretation of actuality. An atheistic worldview can be a naturalistic worldview: essentially, there are actually only atoms and natural forces that we are able to measure.
2006, initially demonstration of molecular sorting in a lab on the chip working with biomotors; discovery of nanobubbles in solid-state nanopores; and 1st estimate of electrokinetic Electrical power conversion inside a nanofluidic channel
Permit’s to start with look back in the mean time if you chose to change your concentration from superconductivity and nanotubes to biology at the conclusion of the 1990s.
Supercoiling-dependent DNA binding: quantitative modeling and programs to bulk and solitary-molecule experiments